Combination antifungal therapy for Scedosporium species in cystic fibrosis.
Pediatr Pulmonol
; 55(8): 1993-1995, 2020 08.
Article
em En
| MEDLINE
| ID: mdl-32339450
ABSTRACT
OBJECTIVE:
To evaluate safety and efficacy of oral posaconazole and terbinafine for Lomentospora prolificans and Scedosporium apiospermum in children with cystic fibrosis.METHODS:
Retrospective case review.RESULTS:
There were five children (four girls), median age 15.0 years; three had S. apiospermum and two had L. prolificans. Treatment duration median 5 months (range 5-18 m). In no patient was eradication achieved, with the follow-up range being 6 months to 4 years. Effect on lung function was variable but encouraging. No adverse effects were reported, one child had transient elevation of liver enzymes.CONCLUSIONS:
While the combination therapy was well tolerated, it was unsuccessful at eradication.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ascomicetos
/
Triazóis
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Scedosporium
/
Fibrose Cística
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Terbinafina
/
Micoses
/
Antifúngicos
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article