Your browser doesn't support javascript.
loading
Emergence of Mycobacterium leprae Rifampin Resistance Evaluated by Whole-Genome Sequencing after 48 Years of Irregular Treatment.
Avanzi, Charlotte; Maia, Raquel Cristina; Benjak, Andrej; Nery, José Augusto; Sales, Anna Maria; Miranda, Alice; Duppre, Nadia Cristina; Nogueira Brum Fontes, Amanda; Pereira da Silva, Tatiana; Olmo Pinheiro, Roberta; Neves-Manta, Fernanda; Moreira, Suelen Justo Maria; Busso, Philippe; Sarno, Euzenir Nunes; Suffys, Phillip Noel; Cole, Stewart Thomas; Moraes, Milton Ozório.
Afiliação
  • Avanzi C; Global Health Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
  • Maia RC; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.
  • Benjak A; Global Health Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
  • Nery JA; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.
  • Sales AM; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.
  • Miranda A; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.
  • Duppre NC; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.
  • Nogueira Brum Fontes A; Molecular Biology Applied to Diagnosis of Mycobacterial Diseases Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.
  • Pereira da Silva T; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.
  • Olmo Pinheiro R; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.
  • Neves-Manta F; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.
  • Moreira SJM; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.
  • Busso P; Global Health Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
  • Sarno EN; Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.
  • Suffys PN; Molecular Biology Applied to Diagnosis of Mycobacterial Diseases Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.
  • Cole ST; Global Health Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland stewart.cole@pasteur.fr milton.moraes@fiocruz.br.
  • Moraes MO; Institut Pasteur, Paris, France.
Antimicrob Agents Chemother ; 64(7)2020 06 23.
Article em En | MEDLINE | ID: mdl-32340990
ABSTRACT
A case of Mycobacterium leprae rifampin resistance after irregular antileprosy treatments since 1971 is reported. Whole-genome sequencing from four longitudinal samples indicated relapse due to acquired rifampin resistance and not to reinfection with another strain. A putative compensatory mutation in rpoC was also detected. Clinical improvement was achieved using an alternative therapy.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hanseníase / Mycobacterium leprae Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hanseníase / Mycobacterium leprae Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article