Your browser doesn't support javascript.
loading
Investigation of Oxazine and Rhodamine Derivatives as Peripheral Nerve Tissue Targeting Contrast Agent for In Vivo Fluorescence Imaging.
Wang, Lei G; Barth, Connor W; Combs, Jason R; Montaño, Antonio R; Gibbs, Summer L.
Afiliação
  • Wang LG; Biomedical Engineering Department, Oregon Health & Science University, Portland, OR 97201.
  • Barth CW; Biomedical Engineering Department, Oregon Health & Science University, Portland, OR 97201.
  • Combs JR; Biomedical Engineering Department, Oregon Health & Science University, Portland, OR 97201.
  • Montaño AR; Biomedical Engineering Department, Oregon Health & Science University, Portland, OR 97201.
  • Gibbs SL; Biomedical Engineering Department, Oregon Health & Science University, Portland, OR 97201.
Article em En | MEDLINE | ID: mdl-32341618
Accidental nerve transection or injury is a significant morbidity associated with many surgical interventions, resulting in persistent postsurgical numbness, chronic pain, and/or paralysis. Nerve-sparing can be a difficult task due to patient-to-patient variability and the difficulty of nerve visualization in the operating room. Fluorescence image-guided surgery to aid in the precise visualization of vital nerve structures in real time during surgery could greatly improve patient outcomes. To date, all nerve-specific contrast agents emit in the visible range. Developing a near-infrared (NIR) nerve-specific fluorophore is poised to be a challenging task, as a NIR fluorophore must have enough "double-bonds" to reach the NIR imaging window, contradicting the requirement that a nerve-specific agent must have a relatively low molecular weight to cross the blood-nerve-barrier (BNB). Herein we report our efforts to investigate the molecular characteristics for the nerve-specific oxazine fluorophores, as well as their structurally analogous rhodamine fluorophores. Specifically, optical properties, physicochemical properties and their in vivo nerve specificity were evaluated herein.
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article