HIV and opiates dysregulate K<sup>+</sup>- Cl<sup>-</sup> cotransporter 2 (KCC2) to cause GABAergic dysfunction in primary human neurons and Tat-transgenic mice.

Barbour, Aaron J; Hauser, Kurt F; McQuiston, A Rory; Knapp, Pamela E

HIV and opiates dysregulate K⁺- Cl^- cotransporter 2 (KCC2) to cause GABAergic dysfunction in primary human neurons and Tat-transgenic mice.

Barbour, Aaron J; Hauser, Kurt F; McQuiston, A Rory; Knapp, Pamela E.

Afiliação

Barbour AJ; Departments of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
Hauser KF; Departments of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA; Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA; Institute for Drug and Alcohol Studies, Virginia Commonwealth University S
McQuiston AR; Departments of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
Knapp PE; Departments of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA; Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA; Institute for Drug and Alcohol Studies, Virginia Commonwealth University S

Neurobiol Dis ; 141: 104878, 2020 07.

Article em En | MEDLINE | ID: mdl-32344154

Assuntos

Analgésicos Opioides/administração & dosagem; HIV-1/fisiologia; Proteínas do Vírus da Imunodeficiência Humana/administração & dosagem; Morfina/administração & dosagem; Neurônios/efeitos dos fármacos; Neurônios/virologia; Simportadores/metabolismo; Ácido gama-Aminobutírico/metabolismo; Animais; Humanos; Masculino; Camundongos Transgênicos; Células-Tronco Neurais/efeitos dos fármacos; Neurônios/metabolismo; Cotransportadores de K e Cl-

Palavras-chave

Archon1; C-C motif chemokine receptor 5 (CCR5); GABA(A) hyperpolarization; GCaMP6f; Intracellular chloride homeostasis; KCC2; Opioid abuse; neuroHIV

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: HIV-1 / Simportadores / Proteínas do Vírus da Imunodeficiência Humana / Ácido gama-Aminobutírico / Analgésicos Opioides / Morfina / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google