CircAtlas: an integrated resource of one million highly accurate circular RNAs from 1070 vertebrate transcriptomes.
Genome Biol
; 21(1): 101, 2020 04 28.
Article
em En
| MEDLINE
| ID: mdl-32345360
ABSTRACT
Existing circular RNA (circRNA) databases have become essential for transcriptomics. However, most are unsuitable for mining in-depth information for candidate circRNA prioritization. To address this, we integrate circular transcript collections to develop the circAtlas database based on 1070 RNA-seq samples collected from 19 normal tissues across six vertebrate species. This database contains 1,007,087 highly reliable circRNAs, of which over 81.3% have been assembled into full-length sequences. We profile their expression pattern, conservation, and functional annotation. We describe a novel multiple conservation score, co-expression, and regulatory networks for circRNA annotation and prioritization. CircAtlas can be accessed at http//circatlas.biols.ac.cn/.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bases de Dados de Ácidos Nucleicos
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Transcriptoma
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RNA Circular
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article