Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags.

Han, Jiaying; Sun, Jing; Song, Shanshan; Beljaars, Leonie; Groothuis, Geny M M; Permentier, Hjalmar; Bischoff, Rainer; Halmos, Gyorgy B; Verhoeven, Cornelia J; Amstalden van Hove, Erika R; Horvatovich, Peter; Casini, Angela

Han, Jiaying; Sun, Jing; Song, Shanshan; Beljaars, Leonie; Groothuis, Geny M M; Permentier, Hjalmar; Bischoff, Rainer; Halmos, Gyorgy B; Verhoeven, Cornelia J; Amstalden van Hove, Erika R; Horvatovich, Peter; Casini, Angela.

Afiliação

Han J; Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. p.l.horvatovich@rug.nl.

Chem Commun (Camb) ; 56(44): 5941-5944, 2020 Jun 04.

Article em En | MEDLINE | ID: mdl-32347235

ABSTRACT

ABSTRACT

Targeted epitope-based mass spectrometry imaging (MSI) utilizes laser cleavable mass-tags bound to targeting moieties for detecting proteins in tissue sections. Our work constitutes the first proof-of-concept of a novel laser desorption ionization (LDI)-MSI strategy using photocleavable Ru(ii) polypyridine complexes as mass-tags for imaging of integrins αvß3 in human cancer tissues.

Assuntos

Neoplasias de Cabeça e Pescoço/metabolismo; Integrina alfaVbeta3/metabolismo; Peptídeos Cíclicos/farmacologia; Piridinas/farmacologia; Rutênio/farmacologia; Humanos; Espectrometria de Massas/métodos; Peptídeos Cíclicos/química; Piridinas/química; Rutênio/química

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos / Piridinas / Rutênio / Integrina alfaVbeta3 / Neoplasias de Cabeça e Pescoço Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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