Rational Design Principles of Attenuated Cationic Lytic Peptides for Intracellular Delivery of Biomacromolecules.

Tamemoto, Naoki; Akishiba, Misao; Sakamoto, Kentarou; Kawano, Kenichi; Noguchi, Hiroshi; Futaki, Shiroh

Tamemoto, Naoki; Akishiba, Misao; Sakamoto, Kentarou; Kawano, Kenichi; Noguchi, Hiroshi; Futaki, Shiroh.

Afiliação

Tamemoto N; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.
Akishiba M; Institute for Solid State Physics, University of Tokyo, Kashiwa, Chiba 277-8581, Japan.
Sakamoto K; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.
Kawano K; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.
Noguchi H; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.
Futaki S; Institute for Solid State Physics, University of Tokyo, Kashiwa, Chiba 277-8581, Japan.

Mol Pharm ; 17(6): 2175-2185, 2020 06 01.

Article em En | MEDLINE | ID: mdl-32352304

Assuntos

Cátions/química; Peptídeos/química; Membrana Celular/metabolismo; Endossomos/metabolismo; Ácido Glutâmico/química; Células HeLa; Humanos; Simulação de Dinâmica Molecular

Palavras-chave

attenuated cationic lytic peptide; endosome-destabilizing peptide; intracellular delivery

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Cátions Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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