Wnt/<b>ß</b>-catenin signaling regulates brain-derived neurotrophic factor release from spinal microglia to mediate HIV<sub>1</sub> gp120-induced neuropathic pain.

Zhou, Xinxin; Tao, Lei; Zhao, Mengru; Wu, Shengjun; Obeng, Enoch; Wang, Dan; Zhang, Wenping

Wnt/ß-catenin signaling regulates brain-derived neurotrophic factor release from spinal microglia to mediate HIV₁ gp120-induced neuropathic pain.

Zhou, Xinxin; Tao, Lei; Zhao, Mengru; Wu, Shengjun; Obeng, Enoch; Wang, Dan; Zhang, Wenping.

Afiliação

Zhou X; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.
Tao L; School of Life Sciences, East China Normal University, Shanghai, China.
Zhao M; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.
Wu S; Clinical Laboratory of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Obeng E; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.
Wang D; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.
Zhang W; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.

Mol Pain ; 16: 1744806920922100, 2020.

Article em En | MEDLINE | ID: mdl-32354292

Assuntos

Fator Neurotrófico Derivado do Encéfalo/metabolismo; Proteína gp120 do Envelope de HIV/efeitos adversos; Microglia/metabolismo; Neuralgia/metabolismo; Medula Espinal/patologia; Via de Sinalização Wnt; Animais; Comportamento Animal; Proteína gp120 do Envelope de HIV/administração & dosagem; Hiperalgesia/complicações; Hiperalgesia/patologia; Injeções Espinhais; Camundongos Endogâmicos ICR; Modelos Biológicos; Neuralgia/complicações; Nociceptividade; Receptor trkB/metabolismo; Receptores de Fator de Crescimento Neural/metabolismo; Regulação para Cima

Palavras-chave

HIV-associated neuropathic pain; Wing-Int; brain-derived neurotrophic factor; microglia; spinal cord

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medula Espinal / Proteína gp120 do Envelope de HIV / Microglia / Fator Neurotrófico Derivado do Encéfalo / Via de Sinalização Wnt / Neuralgia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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