The structural differences between patient-derived &#945;-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies.

Van der Perren, Anke; Gelders, Géraldine; Fenyi, Alexis; Bousset, Luc; Brito, Filipa; Peelaerts, Wouter; Van den Haute, Chris; Gentleman, Steve; Melki, Ronald; Baekelandt, Veerle

The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson's disease, multiple system atrophy and dementia with Lewy bodies.

Van der Perren, Anke; Gelders, Géraldine; Fenyi, Alexis; Bousset, Luc; Brito, Filipa; Peelaerts, Wouter; Van den Haute, Chris; Gentleman, Steve; Melki, Ronald; Baekelandt, Veerle.

Afiliação

Van der Perren A; Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, Leuven, Belgium. Anke.vanderperren@kuleuven.be.
Gelders G; Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, Leuven, Belgium.
Fenyi A; Institut François Jacob (MIRCen), CEA, and Laboratory of Neurodegenerative Diseases, CNRS, Fontenay-aux-Roses, France.
Bousset L; Institut François Jacob (MIRCen), CEA, and Laboratory of Neurodegenerative Diseases, CNRS, Fontenay-aux-Roses, France.
Brito F; Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, Leuven, Belgium.
Peelaerts W; Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, Leuven, Belgium.
Van den Haute C; Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, Leuven, Belgium.
Gentleman S; KU Leuven, Leuven Viral Vector Core, Leuven, Belgium.
Melki R; Neuropathology Unit, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK.
Baekelandt V; Institut François Jacob (MIRCen), CEA, and Laboratory of Neurodegenerative Diseases, CNRS, Fontenay-aux-Roses, France. Ronald.melki@cnrs.fr.

Acta Neuropathol ; 139(6): 977-1000, 2020 06.

Article em En | MEDLINE | ID: mdl-32356200

Assuntos

Demência/patologia; Doença por Corpos de Lewy/patologia; Atrofia de Múltiplos Sistemas/patologia; Doença de Parkinson/patologia; alfa-Sinucleína/metabolismo; Idoso; Idoso de 80 Anos ou mais; Encéfalo/patologia; Feminino; Humanos; Masculino; Pessoa de Meia-Idade

Palavras-chave

Neurodegenerative disorders; Strains; Synucleinopathies; α-synuclein

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Atrofia de Múltiplos Sistemas / Doença por Corpos de Lewy / Demência / Alfa-Sinucleína Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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