Omalizumab in children and adolescents with chronic spontaneous urticaria: Case series and review of the literature.
Dermatol Ther
; 33(4): e13489, 2020 07.
Article
em En
| MEDLINE
| ID: mdl-32358910
ABSTRACT
The recent EAACI/GA2 LEN/EDF/WAO guidelines recommend omalizumab (anti-IgE) for the management of patients aged ≥12 years with chronic urticaria unresponsive to high-doses second-generation H1 -antihistamines (antiH1 ). However, there is little published information on the success of omalizumab for such a treatment in children. We reported our experience of six patients with chronic spontaneous urticaria (CSU) treated with omalizumab. Mean age of our case series was 14.7 years (range 11-16 years) with a prevalence of male gender (66.7%). All six patients were treated with at least one 6-months course of omalizumab. The average follow-up period was 13 ± 6 months. Only one patient was no responder to omalizumab therapy. Thus far, two patients have experienced a complete CSU regression over 12 months after the final omalizumab administration. The remaining three patients needed a second course of treatment. Our experience demonstrates that omalizumab is effective and safe as treatment option for CSU unresponsive to antiH1 , even in adolescent age.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Urticária
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Antialérgicos
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Urticária Crônica
Tipo de estudo:
Diagnostic_studies
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Guideline
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Risk_factors_studies
Limite:
Adolescent
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Aged
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Child
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Humans
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Male
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article