Longitudinal alteration of cortical thickness and volume in high-impact sports.

Mills, Brian D; Goubran, Maged; Parivash, Sherveen N; Dennis, Emily L; Rezaii, Paymon; Akers, Carolyn; Bian, Wei; Mitchell, Lex A; Boldt, Brian; Douglas, David; Sami, Sohrab; Mouchawar, Nicole; Wilson, Eugene W; DiGiacomo, Phil; Parekh, Mansi; Do, Huy; Lopez, Jaime; Rosenberg, Jarrett; Camarillo, David; Grant, Gerald; Wintermark, Max; Zeineh, Michael

Mills, Brian D; Goubran, Maged; Parivash, Sherveen N; Dennis, Emily L; Rezaii, Paymon; Akers, Carolyn; Bian, Wei; Mitchell, Lex A; Boldt, Brian; Douglas, David; Sami, Sohrab; Mouchawar, Nicole; Wilson, Eugene W; DiGiacomo, Phil; Parekh, Mansi; Do, Huy; Lopez, Jaime; Rosenberg, Jarrett; Camarillo, David; Grant, Gerald; Wintermark, Max; Zeineh, Michael.

Afiliação

Mills BD; Department of Radiology, Stanford University, Stanford, CA, 94035, USA. Electronic address: millsb@stanford.edu.
Goubran M; Department of Radiology, Stanford University, Stanford, CA, 94035, USA; Department of Medical Biophysics, University of Toronto, Canada; Hurvitz Brain Sciences Program and Physical Sciences Platform, Sunnybrook Research Institute, University of Toronto, Canada. Electronic address: mgoubran@stanford.
Parivash SN; Department of Radiology, Stanford University, Stanford, CA, 94035, USA. Electronic address: parivash@stanford.edu.
Dennis EL; Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, 84132, USA. Electronic address: Emily.Dennis@hsc.utah.edu.
Rezaii P; Department of Neurosurgery, Stanford University, Stanford, CA, 94035, USA. Electronic address: prezaii@stanford.edu.
Akers C; Department of Radiology, Stanford University, Stanford, CA, 94035, USA. Electronic address: cakers@stanford.edu.
Bian W; Department of Radiology, Stanford University, Stanford, CA, 94035, USA. Electronic address: wei.bian@stanford.edu.
Mitchell LA; Department of Radiology, Stanford University, Stanford, CA, 94035, USA. Electronic address: lexflex5235@gmail.com.
Boldt B; Department of Radiology, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA; Department of Radiology, Madigan Army Medical Center, Tacoma, WA, 98431, USA. Electronic address: boldtb@hotmail.com.
Douglas D; Department of Radiology, Stanford University, Stanford, CA, 94035, USA. Electronic address: ddouglas@stanford.edu.
Sami S; Stanford Center for Clinical Research, Stanford, CA, 94304, USA. Electronic address: ssami@stanford.edu.
Mouchawar N; Department of Radiology, Stanford University, Stanford, CA, 94035, USA. Electronic address: nmouchaw@stanford.edu.
Wilson EW; Department of Radiology, Stanford University, Stanford, CA, 94035, USA. Electronic address: eugene.wilson303@gmail.com.
DiGiacomo P; Department of Radiology, Stanford University, Stanford, CA, 94035, USA. Electronic address: pdigiaco@stanford.edu.
Parekh M; Department of Radiology, Stanford University, Stanford, CA, 94035, USA. Electronic address: mansibparekh@gmail.com.
Do H; Department of Radiology, Stanford University, Stanford, CA, 94035, USA. Electronic address: huymdo@stanford.edu.
Lopez J; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94035, USA. Electronic address: lopezjr@stanford.edu.
Rosenberg J; Department of Radiology, Stanford University, Stanford, CA, 94035, USA. Electronic address: Jarrett.Rosenberg@Stanford.EDU.
Camarillo D; Department of Bioengineering, Stanford University, Stanford, CA, 94035, USA. Electronic address: dcamarillo@stanford.edu.
Grant G; Department of Neurosurgery, Stanford University, Stanford, CA, 94035, USA. Electronic address: ggrant2@stanford.edu.
Wintermark M; Department of Radiology, Stanford University, Stanford, CA, 94035, USA. Electronic address: max.wintermark@gmail.com.
Zeineh M; Department of Radiology, Stanford University, Stanford, CA, 94035, USA. Electronic address: mzeineh@stanford.edu.

Neuroimage ; 217: 116864, 2020 08 15.

Article em En | MEDLINE | ID: mdl-32360690

ABSTRACT

ABSTRACT

Collegiate football athletes are subject to repeated head impacts. The purpose of this study was to determine whether this exposure can lead to changes in brain structure. This prospective cohort study was conducted with up to 4 years of follow-up on 63 football (high-impact) and 34 volleyball (control) male collegiate athletes with a total of 315 MRI scans (after exclusions football n â= â50, volleyball n â= â24, total scans â= â273) using high-resolution structural imaging. Volumetric and cortical thickness estimates were derived using FreeSurfer 5.3's longitudinal pipeline. A linear mixed-effects model assessed the effect of group (football vs. volleyball), time from baseline MRI, and the interaction between group and time. We confirmed an expected developmental decrement in cortical thickness and volume in our cohort (p â< â.001). Superimposed on this, total cortical gray matter volume (p â= â.03) and cortical thickness within the left hemisphere (p â= â.04) showed a group by time interaction, indicating less age-related volume reduction and thinning in football compared to volleyball athletes. At the regional level, sport by time interactions on thickness and volume were identified in the left orbitofrontal (p â= â.001), superior temporal (p â= â.001), and postcentral regions (p â< â.001). Additional cortical thickness interactions were found in the left temporal pole (p â= â.003) and cuneus (p â= â.005). At the regional level, we also found main effects of sport in football athletes characterized by reduced volume in the right hippocampus (p â= â.003), right superior parietal cortical gray (p â< â.001) and white matter (p â< â.001), and increased volume of the left pallidum (p â= â.002). Within football, cortical thickness was higher with greater years of prior play (left hemisphere p â= â.013, right hemisphere p â= â.005), and any history of concussion was associated with less cortical thinning (left hemisphere p â= â.010, right hemisphere p â= â.011). Additionally, both position-associated concussion risk (p â= â.002) and SCAT scores (p â= â.023) were associated with less of the expected volume decrement of deep gray structures. This prospective longitudinal study comparing football and volleyball athletes shows divergent age-related trajectories of cortical thinning, possibly reflecting an impact-related alteration of normal cortical development. This warrants future research into the underlying mechanisms of impacts to the head on cortical maturation.

Assuntos

Córtex Cerebral/diagnóstico por imagem; Córtex Cerebral/lesões; Futebol Americano/lesões; Adolescente; Adulto; Atletas; Encéfalo/diagnóstico por imagem; Concussão Encefálica/diagnóstico por imagem; Estudos de Coortes; Lateralidade Funcional; Substância Cinzenta/diagnóstico por imagem; Humanos; Estudos Longitudinais; Imageamento por Ressonância Magnética; Masculino; Estudos Prospectivos; Voleibol/lesões; Adulto Jovem

Palavras-chave

College football; Cortical thickness and volume; High-impact sports; Structural brain development

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Córtex Cerebral / Futebol Americano Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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