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Ethambutol disposition in humans: Challenges and limitations of whole-body physiologically-based pharmacokinetic modelling in early drug development.
Carrara, Letizia; Magni, Paolo; Teutonico, Donato; Pasotti, Lorenzo; Della Pasqua, Oscar; Kloprogge, Frank.
Afiliação
  • Carrara L; Laboratory of Bioinformatics, Mathematical Modelling and Synthetic Biology, Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Italy.
  • Magni P; Laboratory of Bioinformatics, Mathematical Modelling and Synthetic Biology, Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Italy.
  • Teutonico D; Translational Medicine and Early Development, Sanofi R&D, France.
  • Pasotti L; Laboratory of Bioinformatics, Mathematical Modelling and Synthetic Biology, Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Italy.
  • Della Pasqua O; Clinical Pharmacology & Therapeutics Group, School of Pharmacy, University College London, United Kingdom; Clinical Pharmacology Modelling & Simulation. GlaxoSmithKline, United Kingdom. Electronic address: o.dellapasqua@ucl.ac.uk.
  • Kloprogge F; Clinical Pharmacology & Therapeutics Group, School of Pharmacy, University College London, United Kingdom; Institute for Global Health, University College London, United Kingdom.
Eur J Pharm Sci ; 150: 105359, 2020 Jul 01.
Article em En | MEDLINE | ID: mdl-32361179
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Etambutol / Desenvolvimento de Medicamentos / Modelos Biológicos / Antituberculosos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Etambutol / Desenvolvimento de Medicamentos / Modelos Biológicos / Antituberculosos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article