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Mitochondrial unfolded protein response, mitophagy and other mitochondrial quality control mechanisms in heart disease and aged heart.
Svagusa, Tomo; Martinic, Mislav; Martinic, Matea; Kovacevic, Lucija; Sepac, Ana; Milicic, Davor; Bulum, Josko; Starcevic, Boris; Sirotkovic-Skerlev, Maja; Seiwerth, Fran; Kulic, Ana; Sedlic, Filip.
Afiliação
  • Sedlic F; Filip Sedlic, Department of Pathophysiology, University of Zagreb School of Medicine, Kispaticeva 12, 10 000 Zagreb, Croatia, filip.sedlic@mef.hr.
Croat Med J ; 61(2): 126-138, 2020 Apr 30.
Article em En | MEDLINE | ID: mdl-32378379
Mitochondria are involved in crucial homeostatic processes in the cell: the production of adenosine triphosphate and reactive oxygen species, and the release of pro-apoptotic molecules. Thus, cell survival depends on the maintenance of proper mitochondrial function by mitochondrial quality control. The most important mitochondrial quality control mechanisms are mitochondrial unfolded protein response, mitophagy, biogenesis, and fusion-fission dynamics. This review deals with mitochondrial quality control in heart diseases, especially myocardial infarction and heart failure. Some previous studies have demonstrated that the activation of mitochondrial quality control mechanisms may be beneficial for the heart, while others have shown that it may lead to heart damage. Our aim was to describe the mechanisms by which mitochondrial quality control contributes to heart protection or damage and to provide evidence that may resolve the seemingly contradictory results from the previous studies.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resposta a Proteínas não Dobradas / Mitofagia / Cardiopatias / Mitocôndrias Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resposta a Proteínas não Dobradas / Mitofagia / Cardiopatias / Mitocôndrias Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article