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Targeting defective sphingosine kinase 1 in Niemann-Pick type C disease with an activator mitigates cholesterol accumulation.
Newton, Jason; Palladino, Elisa N D; Weigel, Cynthia; Maceyka, Michael; Gräler, Markus H; Senkal, Can E; Enriz, Ricardo D; Marvanova, Pavlina; Jampilek, Josef; Lima, Santiago; Milstien, Sheldon; Spiegel, Sarah.
Afiliação
  • Newton J; Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA. Electronic address: newtonjc2@vcu.edu.
  • Palladino END; Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
  • Weigel C; Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
  • Maceyka M; Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
  • Gräler MH; Department of Anesthesiology and Intensive Care Medicine, Center for Sepsis Control and Care (CSCC), and Center for Molecular Biomedicine (CMB), University Hospital Jena, Jena, Germany.
  • Senkal CE; Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
  • Enriz RD; Facultad de Quimica, Bioquimica, y Farmacia, Universidad Nacional de San Luis, Instituto Multidisciplinario de Investigaciones Biológicas (IMIBIO-CONICET), San Luis, Argentina.
  • Marvanova P; Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
  • Jampilek J; Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia.
  • Lima S; Department of Biology, Virginia Commonwealth University, Richmond, Virginia, USA.
  • Milstien S; Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
  • Spiegel S; Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA. Electronic address: sarah.spiegel@vcuhealth.org.
J Biol Chem ; 295(27): 9121-9133, 2020 07 03.
Article em En | MEDLINE | ID: mdl-32385114
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esfingosina / Fosfotransferases (Aceptor do Grupo Álcool) / Doença de Niemann-Pick Tipo C Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esfingosina / Fosfotransferases (Aceptor do Grupo Álcool) / Doença de Niemann-Pick Tipo C Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article