Clinical remission of ulcerative colitis after different modes of faecal microbiota transplantation: a meta-analysis.
Int J Colorectal Dis
; 35(6): 1025-1034, 2020 Jun.
Article
em En
| MEDLINE
| ID: mdl-32388604
ABSTRACT
BACKGROUND:
Ulcerative colitis (UC) is a chronic, recurrent and destructive disease of the gastrointestinal tract. Faecal microbiota transplantation (FMT) is a therapeutic measure in which faecal microbiota from healthy people is transplanted into patients.AIM:
To systematically evaluate the safety and effectiveness of treating UC with different modes of FMT.METHODS:
Seven databases were searched by two independent researchers and studies related to randomized controlled trials were included in the analysis.RESULTS:
Seven studies on UC involving 431 patients were included in the analysis. The results showed that FMT had better efficacy than placebo (OR = 2.29, 95% CI 1.48-3.53, P = 0.0002). Subgroup analyses of influencing factors showed that frozen faeces from multiple donors delivered via the lower gastrointestinal tract had a better curative effect than placebo (OR = 2.76, 95% CI 1.59-4.79, P = 0.0003; OR = 2.93, 95% CI 1.67-5.71, P = 0.0002; and OR = 2.70, 95% CI 1.67-4.37, P < 0.0001); the difference in efficacy between mixed faeces from a single donor transplanted through the upper gastrointestinal tract and placebo was not significant(P = 0.05, P = 0.09 and P = 0.98). The analysis of side effects showed no significant difference between FMT and placebo (P = 0.43).CONCLUSIONS:
It may be safe and effective to transplant frozen faeces from multiple donors through the lower gastrointestinal tract to treat UC.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colite Ulcerativa
/
Transplante de Microbiota Fecal
Tipo de estudo:
Clinical_trials
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article