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Direct measurement of cardiac stiffness using echocardiographic shearwave imaging during open-chest surgery: A pilot study in human.
Saloux, Eric; Gauthier, Michael; Buklas, Dimitrios; Saplacan, Vladimir; Denoyer, Antoine; Labombarda, Fabien; Raitiere, Olivier; Criton, Aline; Milliez, Paul; Bauer, Fabrice.
Afiliação
  • Saloux E; Department of cardiology and Caen Basse-Normandie University, Caen University Hospital, Caen, France.
  • Gauthier M; Department of cardiology, Caen University Hospital, Caen, France.
  • Buklas D; Department of cardiac surgery, Caen University Hospital, Caen, France.
  • Saplacan V; Department of cardiac surgery, Caen University Hospital, Caen, France.
  • Denoyer A; Statistician, Soladis, Lyon, France.
  • Labombarda F; Department of cardiology and Caen Basse-Normandie University, Caen University Hospital, Caen, France.
  • Raitiere O; Department of cardiology, Rouen University Hospital, Rouen, France.
  • Criton A; Supersonics Imaging, Aix-en-Provence, France.
  • Milliez P; Department of cardiology and Caen Basse-Normandie University, Caen University Hospital, Caen, France.
  • Bauer F; Pulmonary Hypertension and Advanced Heart Failure Clinic, Department of Cardiac Surgery, INSERM U1096, Rouen University Hospital, Rouen, France.
Echocardiography ; 37(5): 722-731, 2020 05.
Article em En | MEDLINE | ID: mdl-32388915
ABSTRACT

PURPOSE:

Cardiac stiffness is a marker of diastolic function with a strong prognostic significance in many heart diseases that is not measurable in clinical practice. This study investigates whether elastometry, a surrogate for organ stiffness, is measurable in the heart using ShearWave Imaging.

METHODS:

In 33 anesthetized patients scheduled for cardiac surgery, ShearWave imaging was acquired epicardially using a dedicated ultrasound machine on the left ventricle parallel to the left anterior descending coronary artery in a loaded heart following the last cardiac beat. Cardiac elastometry was measured offline using the Young modulus with customized software.

RESULTS:

Overall, the ejection fraction was 61 ± 10%. E/A and E/e' ratios were 1.0 ± 0.5 and 10.5 ± 4.1, respectively. Cardiac elastometry averaged 15.3 ± 5.3 kPa with a median of 18 kPa. Patients with high elastometry >18 kPa were older (P = .04), had thicker (P = .02) but smaller LV (P = .004), had larger left atria (P = .05) and a higher BNP level (P = .04). We distinguished three different transmural elastometry patterns higher epicardial, higher endocardial, or uniformly distributed elastometry.

CONCLUSION:

Elastometry measurement was feasible for the human heart. This surrogate for cardiac stiffness dichotomized patients with low and high elastometry, and provided three different phenotypes of transmural elastometry with link to diastolic function.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disfunção Ventricular Esquerda Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disfunção Ventricular Esquerda Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article