Test-retest repeatability and software reproducibility of myocardial flow measurements using rest/adenosine stress Rubidium-82 PET/CT with and without motion correction in healthy young volunteers.
J Nucl Cardiol
; 28(6): 2860-2871, 2021 12.
Article
em En
| MEDLINE
| ID: mdl-32390111
ABSTRACT
BACKGROUND:
Myocardial flow reserve (MFR) assessment with cardiac positron emission computed tomography (PET/CT) is well established, and quantification relies on commercial software packages. However, for reliable use, repeatability and reproducibility are important. The aim of this study was therefore to investigate and compare between scans and software packages the repeatability and reproducibility of 82Rb-PET/CT estimated MFR. METHODS ANDRESULTS:
Forty healthy volunteers completed two 82Rb-PET/CT rest and adenosine stress scans. syngo.MBF (Siemens), quantitative-gated SPECT (QGS) (Cedars-Sinai), and Corridor4DM (4DM) were used for analyses. Motion correction was available for 4DM. Fifty percent were men and age was 24 ± 4 years (mean ± SD). Repeatability of MFR varied between scans. syngo.MBF mean difference (95% CI) 0.26 (- 0.03 to 0.54), P = 0.07, limits of agreement (LoA) - 1.43 to 1.95; QGS 0.19 (- 0.08 to 0.46), P = 0.15, LoA - 1.38 to 1.76; 4DM 0.08 (- 0.17 to 0.34), P = 0.50, LoA - 1.37 to 1.53; and 4DM motion corrected 0.17 (- 0.17 to 0.51), P = 0.32, LoA - 1.89 to 2.22. MFR was higher using 4DM +/- motion correction compared with syngo.MBF and QGS (all P < 0.0001). Concordance between syngo.MBF and QGS was high (P = 0.83).CONCLUSIONS:
Reproducibility of MFR varied for the different software. The highest concordance between MFRs was found between syngo.MBF and QGS.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Software
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Radioisótopos de Rubídio
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Circulação Coronária
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Teste de Esforço
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Imagem de Perfusão do Miocárdio
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Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article