Protection and Isolation of Bioorthogonal Metal Catalysts by Using Monolayer-Coated Nanozymes.
Chembiochem
; 21(19): 2759-2763, 2020 10 01.
Article
em En
| MEDLINE
| ID: mdl-32400081
ABSTRACT
We demonstrate here the protection of biorthogonal transition metal catalysts (TMCs) in biological environments by using self-assembled monolayers on gold nanoparticles (AuNPs). Encapsulation of TMCs in this hydrophobic environment preserves catalytic activity in presence of pH conditions and complex biological media that would deactivate free catalyst. Significantly, the protection affords by these nanozymes extends to isolation of the catalyst active site, as demonstrated by the independence of rate over a wide pH range, in strong contrast to the behavior of the free catalyst.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Metais Pesados
/
Nanoestruturas
/
Complexos de Coordenação
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article