Effects of dexmedetomidine on new oxidative stress markers on renal ischaemia-reperfusion injury in rats: thiol/disulphide homeostasis and the ischaemia-modified albumin.
Arch Physiol Biochem
; 128(4): 1115-1120, 2022 Aug.
Article
em En
| MEDLINE
| ID: mdl-32401057
ABSTRACT
OBJECTIVES:
This study investigated the effect of dexmedetomidine on the oxidant-antioxidant (thiol/disulphide) balance.METHODS:
A total of 24 rats were divided into four groups. The renal arteries in groups IR (ischaemia/reperfusion) and IR + D (ischaemia/reperfusion + dexmedetomidine) were clamped for 45 min and reperfused for 180 min. Groups D (Dexmedetomidine) and IR + D were administered 100 µg/kg dexmedetomidine. Oxidant-antioxidant (thiol/disulphide) levels were measured. Kidney tissue was examined histopathologically.RESULTS:
No statistically difference was found between the groups in terms of thiol-disulphide averages, while IMA, TOS and thiol-disulphide results showed a minimal decrease in Group IR + D compared to Group IR (p > 0.05). Tubular lesions and necrosis were found in 26-50% of tubules in Group IR. Tubular damage and necrosis in Group IR + D declined to 5-25% .CONCLUSIONS:
No statistically difference was found in the study where OSI index, thiol/disulphide balance and IMA were measured together as biochemical values.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Traumatismo por Reperfusão
/
Dexmedetomidina
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article