Organocatalytic trans Phosphinoboration of Internal Alkynes.
Angew Chem Int Ed Engl
; 59(34): 14358-14362, 2020 Aug 17.
Article
em En
| MEDLINE
| ID: mdl-32406101
ABSTRACT
We report the first trans phosphinoboration of internal alkynes. With an organophosphine catalyst, alkynoate esters and the phosphinoboronate Ph2 P-Bpin are efficiently converted into the corresponding trans-α-phosphino-ß-boryl acrylate products in moderate to good yield with high regio- and Z-selectivity. This reaction operates under mild conditions and demonstrates good atom economy, requiring only a modest excess of the phosphinoboronate. X-ray crystallography experiments allowed structural assignment of the unprecedented and densely functionalized (Z)-α-phosphino-ß-boryl acrylate products.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article