Real-Time Inâ
Vivo Detection of Cellular Senescence through the Controlled Release of the NIR Fluorescent Dye Nile Blue.
Angew Chem Int Ed Engl
; 59(35): 15152-15156, 2020 08 24.
Article
em En
| MEDLINE
| ID: mdl-32416002
ABSTRACT
Inâ
vivo detection of cellular senescence is accomplished by using mesoporous silica nanoparticles loaded with the NIR-FDA approved Nile blue (NB) dye and capped with a galactohexasaccharide (S3). NB emission at 672â
nm is highly quenched inside S3, yet a remarkable emission enhancement is observed upon cap hydrolysis in the presence of ß-galactosidase and dye release. The efficacy of the probe to detect cellular senescence is tested inâ
vitro in melanoma SK-Mel-103 and breast cancer 4T1 cells and inâ
vivo in palbociclib-treated BALB/cByJ mice bearing breast cancer tumor.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Senescência Celular
/
Corantes Fluorescentes
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article