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Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes.
Saleem, Umber; van Meer, Berend J; Katili, Puspita A; Mohd Yusof, Nurul A N; Mannhardt, Ingra; Garcia, Ana Krotenberg; Tertoolen, Leon; de Korte, Tessa; Vlaming, Maria L H; McGlynn, Karen; Nebel, Jessica; Bahinski, Anthony; Harris, Kate; Rossman, Eric; Xu, Xiaoping; Burton, Francis L; Smith, Godfrey L; Clements, Peter; Mummery, Christine L; Eschenhagen, Thomas; Hansen, Arne; Denning, Chris.
Afiliação
  • Saleem U; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, and DZHK (German Center for Cardiovascular Research), Partner Site, Hamburg/Kiel/Lübeck, Germany.
  • van Meer BJ; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZD, Leiden, The Netherlands.
  • Katili PA; Department of Stem Cell Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
  • Mohd Yusof NAN; Department of Stem Cell Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
  • Mannhardt I; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, and DZHK (German Center for Cardiovascular Research), Partner Site, Hamburg/Kiel/Lübeck, Germany.
  • Garcia AK; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZD, Leiden, The Netherlands.
  • Tertoolen L; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZD, Leiden, The Netherlands.
  • de Korte T; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZD, Leiden, The Netherlands.
  • Vlaming MLH; Ncardia, 2333 BD, Leiden, The Netherlands.
  • McGlynn K; Ncardia, 2333 BD, Leiden, The Netherlands.
  • Nebel J; Clyde Biosciences Ltd, Biocity Scotland, Newhouse, Lanarkshire ML1 5HU, UK.
  • Bahinski A; Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, and DZHK (German Center for Cardiovascular Research), Partner Site, Hamburg/Kiel/Lübeck, Germany.
  • Harris K; GlaxoSmithKline, Collegeville, Pennsylvania 19426.
  • Rossman E; NC3Rs, London NW1 2BE, UK.
  • Xu X; GlaxoSmithKline, Collegeville, Pennsylvania 19426.
  • Burton FL; GlaxoSmithKline, Collegeville, Pennsylvania 19426.
  • Smith GL; Clyde Biosciences Ltd, Biocity Scotland, Newhouse, Lanarkshire ML1 5HU, UK.
  • Clements P; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
  • Mummery CL; Clyde Biosciences Ltd, Biocity Scotland, Newhouse, Lanarkshire ML1 5HU, UK.
  • Eschenhagen T; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
  • Hansen A; GlaxoSmithKline, David Jack Centre for R&D, Ware, Hertfordshire SG12 0DP, UK.
  • Denning C; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZD, Leiden, The Netherlands.
Toxicol Sci ; 176(1): 103-123, 2020 07 01.
Article em En | MEDLINE | ID: mdl-32421822
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Miócitos Cardíacos / Relação Dose-Resposta a Droga / Células-Tronco Pluripotentes Induzidas Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Miócitos Cardíacos / Relação Dose-Resposta a Droga / Células-Tronco Pluripotentes Induzidas Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article