Factors associated with the duration of viral shedding in adults with COVID-19 outside of Wuhan, China: a retrospective cohort study.
Int J Infect Dis
; 96: 531-537, 2020 Jul.
Article
em En
| MEDLINE
| ID: mdl-32425636
ABSTRACT
OBJECTIVES:
To investigate factors associated with the duration of viral shedding in patients with COVID-19, outside of Wuhan.METHODS:
In this retrospective cohort study, patients with laboratory-confirmed COVID-19 in Changsha, China were included. Clinical characteristics, laboratory findings, treatment, and outcome were retrieved. Univariate and multivariate analyses were performed to explore potential factors.RESULTS:
Overall, 147 patients with COVID-19 were included. The median duration of viral shedding (the number of days from symptoms onset until the successive negative detection of SARS-CoV-2 RNA) was 17 days (interquartile range [IQR], 12-21). Multivariate Logistic regression analysis indicated that the highest temperature at admission (odds ratio [OR], 5.200; 95% confidence interval [CI] 1.190-22.726; p = 0.028), time from symptom onset to admission (OR, 1.740; 95% CI 1.296-2.337; p < 0.001) and hospital length of stay (OR, 1.604; 95% CI 1.262-2.040; p < 0.001) were risk factors for prolonged duration of viral shedding.CONCLUSIONS:
This study, with a relatively large sample size, focused on the duration of viral shedding and related factors in patients with COVID-19, outside of Wuhan, China. Potential risk factors were identified and should be taken into consideration for the strategy of quarantining infected patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pneumonia Viral
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Eliminação de Partículas Virais
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Infecções por Coronavirus
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article