A minor structure modification serendipitously leads to a highly carbapenemase-specific fluorogenic probe.
Org Biomol Chem
; 18(21): 4029-4033, 2020 06 07.
Article
em En
| MEDLINE
| ID: mdl-32432265
ABSTRACT
Reported herein is a fluorogenic probe for the detection of carbapenemase activity. This reagent features carbapenem as an enzyme recognition motif and a carbon-carbon double bond between carbapenem and the fluorophore, exhibiting high specificity to all carbapenemases, including metallo carbapenemases and serine carbapenemases, over other ß-lactamases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Beta-Lactamases
/
Corantes Fluorescentes
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article