[Efficacy and safety of fluconazole in prophylaxis of invasive fungal infections in very low birth weight infants: a Meta analysis].
Zhongguo Dang Dai Er Ke Za Zhi
; 22(5): 446-453, 2020 May.
Article
em Zh
| MEDLINE
| ID: mdl-32434639
ABSTRACT
OBJECTIVE:
To assess the efficacy and safety of fluconazole in the prophylaxis of invasive fungal infection in very low birth weight (VLBW) infants.METHODS:
Databases including PubMed, Embase, the Cochrane Library, Wanfang Data, Weipu, and CNKI were searched for randomized controlled trials (RCTs) of prophylactic fluconazole in VLBW infants. Review Manager 5.3 software was used to perform a Meta analysis of the included studies.RESULTS:
A total of 12 RCTs were included, involving 1â679 VLBW infants. The Meta analysis showed that prophylactic fluconazole significantly reduced the incidence of invasive fungal infection (RR=0.44, 95%CI 0.27-0.71, P<0.001), the incidence of fungal colonization (RR=0.31, 95%CI 0.24-0.40, P<0.001), and the mortality during hospitalization (RR=0.74, 95%CI 0.58-0.94, P=0.01) compared with the control group. There were no significant differences between VLBW infants using different doses of fluconazole in the incidence of invasive fungal infection and fungal colonization (P>0.05). No significant differences were found in the incidence of fluconazole resistance and complications between the fluconazole and control groups (P>0.05).CONCLUSIONS:
Prophylactic fluconazole can effectively and safely prevent invasive fungal infection in VLBW infants, even at a small dose.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Fúngicas Invasivas
Tipo de estudo:
Systematic_reviews
Limite:
Humans
/
Newborn
Idioma:
Zh
Ano de publicação:
2020
Tipo de documento:
Article