Comparing the Intestinotrophic Effects of 2 Glucagon-Like Peptide-2 Analogues in the Treatment of Short-Bowel Syndrome in Neonatal Piglets.
JPEN J Parenter Enteral Nutr
; 45(3): 538-545, 2021 03.
Article
em En
| MEDLINE
| ID: mdl-32437048
ABSTRACT
BACKGROUND:
In treating short-bowel syndrome (SBS), autonomy from parenteral nutrition (PN) relies upon intestinal adaptation, which can be augmented by glucagon-like peptide-2 (GLP-2) analogues. In neonatal piglets with SBS, we compared intestinal adaptation following treatment with 2 GLP-2 analogues teduglutide (TED) and apraglutide (APRA)METHODS:
Following 75% distal small-intestinal resection, piglets were allocated to 4 treatment groups saline (CON n = 8), twice weekly APRA (5 mg/kg/dose; n = 8), and TED once daily (TED, 0.05 mg/kg/dose; n = 8) or twice daily (TEDBID, 0.05 mg/kg/dose; n = 7). Pharmacokinetic (PK) studies were undertaken, and on day 7, small-intestinal length and weight were measured and jejunal tissue collected for histology.RESULTS:
PK profiles were different between the 2 analogues. To achieve a comparable exposure to APRA, TED requires twice daily injection (TEDBID). Compared with CON, APRA and TEDBID increased small-bowel length (cm) (CON 141, APRA 166, TED 153, TEDBID 165; P = .004), whereas APRA increased small-bowel weight (g) (CON 26, APRA 33, TED 28, TEDBID 31; P = .007) and villus height (mm) (CON 0.59, APRA 0.90, TED 0.58, TEDBID 0.74; P < .001).CONCLUSION:
APRA injected only twice during the 7 consecutive days demonstrated a superior intestinotrophic effect compared with TED injected once daily. Even at more comparable drug exposure, when TED was injected twice a day, APRA showed superior trophic activity at the mucosal level. This is highly relevant for the treatment of pediatric SBS, given the markedly lower dose frequency by subcutaneous injection of APRA.Palavras-chave
Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Intestino Curto
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article