Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors.
Angew Chem Int Ed Engl
; 59(30): 12417-12422, 2020 07 20.
Article
em En
| MEDLINE
| ID: mdl-32441859
ABSTRACT
Flexible multivalent 3D nanosystems that can deform and adapt onto the virus surface via specific ligand-receptor multivalent interactions can efficiently block virus adhesion onto the cell. We here report on the synthesis of a 250â
nm sized flexible sialylated nanogel that adapts onto the influenza A virus (IAV) surface via multivalent binding of its sialic acid (SA) residues with hemagglutinin spike proteins on the virus surface. We could demonstrate that the high flexibility of sialylated nanogel improves IAV inhibition by 400 times as compared to a rigid sialylated nanogel in the hemagglutination inhibition assay. The flexible sialylated nanogel efficiently inhibits the influenza A/X31 (H3N2) infection with IC50 values in low picomolar concentrations and also blocks the virus entry into MDCK-II cells.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Vírus da Influenza A
/
Ácido N-Acetilneuramínico
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Nanogéis
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article