Soluble PD-L1: a potential immune marker for HIV-1 infection and virological failure.
Medicine (Baltimore)
; 99(20): e20065, 2020 May.
Article
em En
| MEDLINE
| ID: mdl-32443313
ABSTRACT
Despite viral control, basal chronic inflammation and its related comorbidities remain unsolved problems among HIV-infected individuals. Soluble factors derived from myeloid cells have emerged as potent markers associated with HIV-related comorbidities and mortality. In the present report, we explored the relationship between soluble programmed death-ligand 1 (sPD-L1) and HIV-1 infection, antiretroviral therapy (ART), CD4/CD8 ratio, viral load (VL), and sexually transmitted coinfections.A prospective observational study on 49 HIV-1 infected adults.We found sPD-L1 levels were significantly higher in 49 HIV infected subjects than in 30 uninfected adults (1.05âng/ml vs 0.52âng/ml; Pâ<â.001). In this line, sPD-L1 levels were found to be elevated in 16 HIV infected subjects with undetectable VL compared with the uninfected subjects (0.75âng/ml vs 0.52âng/ml; P = .02). Thirteen ART-treated individuals with virological failure exhibited the highest sPDL1 levels, which were significantly higher than both 20 ART naïve infected individuals (1.68âng/ml vs 0.87âng/ml; Pâ=â.003) and the 16 ART-treated individuals with suppressed viremia (1.68âng/ml vs 0.79âng/ml; Pâ=â002). Entire cohort data showed a statistically significant positive correlation between VL and sPD-L1 levels in plasma (râ=â0.3; Pâ=â036).Our findings reveal sPDL-1 as a potential biomarker for HIV infection especially interesting in those individuals with virological failure.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
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HIV-1
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Antígeno B7-H1
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article