Crispr/Cas9-mediated cleavages facilitate homologous recombination during genetic engineering of a large chromosomal region.

Zhang, Fan; Cheng, De; Wang, Shuwen; Zhu, Jiyue

Zhang, Fan; Cheng, De; Wang, Shuwen; Zhu, Jiyue.

Afiliação

Zhang F; Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, Washington.
Cheng; Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, Washington.
Wang S; Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, Washington.
Zhu J; Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, Washington.

Biotechnol Bioeng ; 117(9): 2816-2826, 2020 09.

Article em En | MEDLINE | ID: mdl-32449788

Assuntos

Sistemas CRISPR-Cas/genética; Edição de Genes/métodos; Recombinação Homóloga/genética; Animais; Quebras de DNA de Cadeia Dupla; Humanos; Camundongos; Plasmídeos/genética

Palavras-chave

Crispr/Cas9; TERT; knock-in; mESC

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Recombinação Homóloga / Sistemas CRISPR-Cas / Edição de Genes Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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