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Intestinal Absorption and Tissue Distribution of Aza-Sugars from Mulberry Leaves and Evaluation of Their Transport by Sugar Transporters.
Takasu, Soo; Parida, Isabella S; Ito, Junya; Kojima, Yoshihiro; Eitsuka, Takahiro; Kimura, Toshiyuki; Nakagawa, Kiyotaka.
Afiliação
  • Takasu S; Food and Biodynamic Chemistry Laboratory, Tohoku University Graduate School of Agricultural Science Faculty of Agriculture, Graduate School of Agricultural Science 468-1, Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8572, Japan.
  • Parida IS; Food and Biodynamic Chemistry Laboratory, Tohoku University Graduate School of Agricultural Science Faculty of Agriculture, Graduate School of Agricultural Science 468-1, Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8572, Japan.
  • Ito J; Food and Biodynamic Chemistry Laboratory, Tohoku University Graduate School of Agricultural Science Faculty of Agriculture, Graduate School of Agricultural Science 468-1, Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8572, Japan.
  • Kojima Y; Minato Pharmaceutical Co., Ltd., 1-14-11, Ginza, Chuo-ku, Tokyo, 104-0061, Japan.
  • Eitsuka T; Food and Biodynamic Chemistry Laboratory, Tohoku University Graduate School of Agricultural Science Faculty of Agriculture, Graduate School of Agricultural Science 468-1, Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8572, Japan.
  • Kimura T; National Agriculture and Food Research Organization, Division of Food Function Research, 2-1-12 Kannondai, Tsukuba, Ibaraki, 305-8517, Japan.
  • Nakagawa K; Food and Biodynamic Chemistry Laboratory, Tohoku University Graduate School of Agricultural Science Faculty of Agriculture, Graduate School of Agricultural Science 468-1, Aramaki Aza Aoba, Aoba-ku, Sendai, Miyagi, 980-8572, Japan.
J Agric Food Chem ; 68(24): 6656-6663, 2020 Jun 17.
Article em En | MEDLINE | ID: mdl-32449853
Mulberry leaves are rich in aza-sugars, particularly 1-deoxynojirimycin (DNJ), fagomine, and 2-O-α-d-galactopyranosyl-1-deoxynojirimycin (GAL-DNJ), which have antidiabetes and antiobesity properties. To help us understand the mechanisms of action of aza-sugars, pharmacokinetic studies are necessary. Therefore, in this study, we evaluated and compared the absorption and organ distribution of these aza-sugars in rats. Following oral intake, DNJ exhibited the highest plasma concentration followed by fagomine and GAL-DNJ. Meanwhile, similar amounts of DNJ and fagomine were present in organs, while GAL-DNJ was hardly detected, suggesting the diversity in absorption and distribution characteristics of these aza-sugars. We then investigated the role of the sodium-glucose cotransporter and the glucose transporter (GLUT) in the transport of aza-sugars and found that both are involved in DNJ transport, while transport of fagomine is solely facilitated by the GLUT. These findings provide insight into the bioavailability and bioactive mechanisms of these aza-sugars.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Morus / Açúcares / Mucosa Intestinal Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Morus / Açúcares / Mucosa Intestinal Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article