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Low dose intravenous immunoglobulin in addition to cyclophosphamide in systemic sclerosis : Single centre experience.
Perkovic, Dijana; Petric, Marin; Bozic, Ivona; Boric, Katarina; Marasovic Krstulovic, Daniela; Radic, Mislav; Martinovic Kaliterna, Dusanka.
Afiliação
  • Perkovic D; Department of Clinical Immunology and Rheumatology, Department of Internal Medicine, University Hospital of Split, Soltanska 1, 21000, Split, Croatia.
  • Petric M; Department of Clinical Immunology and Rheumatology, Department of Internal Medicine, University Hospital of Split, Soltanska 1, 21000, Split, Croatia. marin.petric2017@gmail.com.
  • Bozic I; Department of Clinical Immunology and Rheumatology, Department of Internal Medicine, University Hospital of Split, Soltanska 1, 21000, Split, Croatia.
  • Boric K; Department of Clinical Immunology and Rheumatology, Department of Internal Medicine, University Hospital of Split, Soltanska 1, 21000, Split, Croatia.
  • Marasovic Krstulovic D; Department of Clinical Immunology and Rheumatology, Department of Internal Medicine, University Hospital of Split, Soltanska 1, 21000, Split, Croatia.
  • Radic M; Department of Clinical Immunology and Rheumatology, Department of Internal Medicine, University Hospital of Split, Soltanska 1, 21000, Split, Croatia.
  • Martinovic Kaliterna D; Department of Clinical Immunology and Rheumatology, Department of Internal Medicine, University Hospital of Split, Soltanska 1, 21000, Split, Croatia.
Wien Klin Wochenschr ; 133(19-20): 1070-1075, 2021 Oct.
Article em En | MEDLINE | ID: mdl-32451820
AIM: Systemic sclerosis (SSc) is a rare chronic disease characterized by pathologic collagen deposits in the skin and internal organs. Although it is considered to be an autoimmune disease, immunosuppressants have a limited effect on severe SSc. Intravenous immunoglobulins (IVIG) have shown favorable effects in patients with SSc by suppressing the action of profibrotic cytokines, so they could have additional effect on standard treatment such as cyclophosphamide (CYC). This article presents the immunomodulatory effect of low-dose IVIG in addition to CYC in the treatment of severe SSc in this center during the last 9 years. METHODS: This retrospective observational study analyzed the medical documentation of nine patients with SSc treated with low-dose IVIG (0.4 g/kg and month) together with intravenous CYC (600 mg/m2 and month). The therapeutic effect on lung and skin manifestations was assessed. RESULTS: Of the patients one had interstitial lung diseases (ILD), two had progressive skin diseases, and six had a combination of skin and lung involvement. The best results were achieved in skin changes, where complete healing of digital ulcers (DU) was recorded in every reported case. A decrease in the modified Rodnan skin score (mRSS) was noted in three patients and increased diffusion capacity of the lungs for carbon monoxide in another three patients. CONCLUSION: The results of the study suggest that IVIG may be an additional treatment option together with CYC for patients for whom other therapies have failed, but further studies on the exact role of IVIG in the treatment of severe SSc are required.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Escleroderma Sistêmico / Doenças Pulmonares Intersticiais Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Escleroderma Sistêmico / Doenças Pulmonares Intersticiais Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article