Adjuvant Thermal Accelerant Gel Use Increases Microwave Ablation Zone Temperature in Porcine Liver as Measured by MR Thermometry.
J Vasc Interv Radiol
; 31(8): 1357-1364, 2020 Aug.
Article
em En
| MEDLINE
| ID: mdl-32457010
ABSTRACT
PURPOSE:
To determine the effects of a thermal accelerant gel on temperature parameters during microwave liver ablation. MATERIALS ANDMETHODS:
Sixteen consecutive liver ablations were performed in 5 domestic swine under general anesthesia with (n = 8) and without (n = 8) administration of thermal accelerant gel. Ablation zone temperature was assessed by real-time MR thermometry, measured as maximum temperature (Tmax) and the volume of tissue ≥ 60°C (V60). Tissue heating rate, ablation zone shape, and thermal energy deposition using the temperature degree-minutes at 43°C (TDM43) index were also measured. Differences between groups were analyzed using generalized mixed modeling with significance set at P = .05.RESULTS:
Mean peak ablation zone temperature was significantly greater with thermal accelerant use (mean Tmax, thermal accelerant 120.0°C, 95% confidence interval [CI] 113.0°C-126.9°C; mean Tmax, control 80.3°C, 95% CI 72.7°C-88.0°C; P < .001), and a significantly larger volume of liver tissue achieved or exceeded 60°C when thermal accelerant was administered (mean V60, thermal accelerant 22.2 cm3; mean V60, control 15.9 cm3; P < .001). Significantly greater thermal energy deposition was observed during ablations performed with accelerant (mean TDM43, thermal accelerant 198.4 min, 95% CI 170.7-230.6 min; mean TDM43, control 82.8 min, 95% CI 80.5-85.1 min; P < .0001). The rate of tissue heating was significantly greater with thermal accelerant use (thermal accelerant 5.8 min ± 0.4; control 10.0 min; P < .001), and accelerant gel ablations demonstrated a more spherical temperature distribution (P = .002).CONCLUSIONS:
Thermal accelerant use is associated with higher microwave ablation zone temperatures, greater thermal energy deposition, and faster and more spherical tissue heating compared with control ablations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
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Cirurgia Assistida por Computador
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Técnicas de Ablação
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Termometria
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Polímeros Responsivos a Estímulos
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Temperatura Alta
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Fígado
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Micro-Ondas
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article