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Functional inhibition of regulatory CD4+CD25+T cells in peripheral blood of patients with pemphigus vulgaris.
Su, W; Zhou, Q; Ke, Y; Xue, J; Shen, J.
Afiliação
  • Su W; Department of Medical Cosmetology, Department of Dermatology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou Skin Disease and Plastic Surgery Hospital, Wenzhou, Zhejiang Province, 325027, China.
  • Zhou Q; Department of Medical Cosmetology, Department of Dermatology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou Skin Disease and Plastic Surgery Hospital, Wenzhou, Zhejiang Province, 325027, China.
  • Ke Y; Department of Medical Cosmetology, Department of Dermatology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou Skin Disease and Plastic Surgery Hospital, Wenzhou, Zhejiang Province, 325027, China.
  • Xue J; Department of Hand and Plastic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
  • Shen J; Department of Dermatology, Huadong Hospital Affiliated with Fudan University, Shanghai, China.
Clin Exp Dermatol ; 45(8): 1019-1026, 2020 Dec.
Article em En | MEDLINE | ID: mdl-32460351
BACKGROUND: Pemphigus vulgaris (PV) is a potentially life-threatening autoimmune bullous disease affecting the skin and mucous membranes. Its pathogenic mechanism is still not fully understood. Regulatory T cells (Tregs) have been reported to play a significant role in regulating immune homeostasis in autoimmune disorders, such as PV. AIM: To investigate the potential role of Tregs in the immunopathogenesis of PV. METHODS: We enrolled 15 patients with PV and 15 healthy controls (HCs). Peripheral blood samples were collected from all participants before treatment. This was followed by flow cytometric, real-time reverse transcription PCR, and in vitro inhibition-based functional assays to explore the immunopathogenesis of Tregs in PV. RESULTS: Our results showed no statistically significant differences in total CD4+CD25+ cells and CD4+CD25high cells. In addition, expression levels of FOXP3 mRNA and the corresponding FOXP3 protein remained unchanged in the patients with PV and the HCs. However, the in vitro suppressive activity of CD4+CD25+ T cells was impaired in patients with PV compared with HCs. CONCLUSIONS: Our observations suggest that inhibition of suppressive activity of Treg cells may be involved in the pathogenesis of PV.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Pênfigo / Linfócitos T Reguladores / Subunidade alfa de Receptor de Interleucina-2 Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Pênfigo / Linfócitos T Reguladores / Subunidade alfa de Receptor de Interleucina-2 Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article