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Late-Stage Lead Diversification Coupled with Quantitative Nuclear Magnetic Resonance Spectroscopy to Identify New Structure-Activity Relationship Vectors at Nanomole-Scale Synthesis: Application to Loratadine, a Human Histamine H1 Receptor Inverse Agonist.
Lall, Manjinder S; Bassyouni, Asser; Bradow, James; Brown, Maria; Bundesmann, Mark; Chen, Jinshan; Ciszewski, Gregory; Hagen, Anne E; Hyek, Dennis; Jenkinson, Stephen; Liu, Bo; Obach, R Scott; Pan, Senliang; Reilly, Usa; Sach, Neal; Smaltz, Daniel J; Spracklin, Douglas K; Starr, Jeremy; Wagenaar, Melissa; Walker, Gregory S.
Afiliação
  • Lall MS; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Bassyouni A; Pfizer Worldwide Research and Development, Science Center Drive, San Diego, California 92121, United States.
  • Bradow J; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Brown M; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Bundesmann M; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Chen J; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Ciszewski G; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Hagen AE; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Hyek D; Spectrix Analytical Services, LLC, 410 Sackett Point Road, Bldg 20, North Haven, Connecticut 06473, United States.
  • Jenkinson S; Pfizer Worldwide Research and Development, Science Center Drive, San Diego, California 92121, United States.
  • Liu B; Spectrix Analytical Services, LLC, 410 Sackett Point Road, Bldg 20, North Haven, Connecticut 06473, United States.
  • Obach RS; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Pan S; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Reilly U; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Sach N; Pfizer Worldwide Research and Development, Science Center Drive, San Diego, California 92121, United States.
  • Smaltz DJ; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Spracklin DK; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Starr J; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Wagenaar M; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
  • Walker GS; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
J Med Chem ; 63(13): 7268-7292, 2020 07 09.
Article em En | MEDLINE | ID: mdl-32462865
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Relação Estrutura-Atividade / Loratadina Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Relação Estrutura-Atividade / Loratadina Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article