Transition-Metal-Free Stereospecific Oxidative Annulative Coupling of Indolines with Aziridines.
J Org Chem
; 85(12): 8261-8270, 2020 06 19.
Article
em En
| MEDLINE
| ID: mdl-32468818
ABSTRACT
Tandem C-N bond formation for the oxidative annulation of indolines with aziridines is accomplished employing the combination of DDQ and NaOCl at ambient conditions. Optically active aziridine can be coupled with high enantiomeric purity (>99% ee). The substrate scope, stereocontrol with the enantioenriched substrate, and scale-up are the important practical advantages.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article