Effect of non-sedation on post-traumatic stress and psychological health in survivors of critical illness-A substudy of the NONSEDA randomized trial.
Acta Anaesthesiol Scand
; 64(8): 1136-1143, 2020 09.
Article
em En
| MEDLINE
| ID: mdl-32470147
ABSTRACT
BACKGROUND:
Critical illness can cause post-traumatic stress and impaired mental health. The NONSEDA trial was a Scandinavian multicenter RCT, assessing non-sedation versus sedation with a daily wake-up call during mechanical ventilation in critically ill adults. The aim of this substudy was to assess the effect of non-sedation on post-traumatic stress and mental health.METHODS:
This substudy is based on all participating patients from a single NONSEDA trial site (Kolding, Denmark). Patients were randomized to sedation or non-sedation within the first 24 hours of mechanical ventilation. Three months after ICU discharge survivors were examined by a neuropsychologist for post-traumatic stress, anxiety and depression, and filled out the SF-36 questionnaire regarding quality of life.RESULTS:
The two groups of survivors were similar with regard to baseline characteristics, length of admission and mechanical ventilation. Sedated patients received more propofol and midazolam. Doses of morphine and haloperidole were equal. PRIMARYOUTCOME:
the number of patients with post-traumatic stress disorder did not differ between groups (non-sedated 2 patients vs sedated 0, P = .23). SECONDARYOUTCOMES:
there were no differences between groups in Beck Anxiety Index (median, non-sedated 0 vs sedated 0, P = .62), Beck Depression Index (median, non-sedated 7 vs sedated 4, P = .24), SF-36 mental component score (mean, non-sedated 46.7 vs sedated 47.5, P = .73) or number of patients with symptoms of post-traumatic stress (8 in both groups, P = .89).CONCLUSION:
Levels of PTSD, anxiety and depression and quality of life regarding mental health were similar between the non-sedated and sedated group.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
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Transtornos de Estresse Pós-Traumáticos
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Cuidados Críticos
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Hipnóticos e Sedativos
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Transtornos Mentais
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article