Melatonin ameliorates pressure overload-induced cardiac hypertrophy by attenuating Atg5-dependent autophagy and activating the Akt/mTOR pathway.

Xu, Chen-Nian; Kong, Ling-Heng; Ding, Peng; Liu, Yang; Fan, Zhen-Ge; Gao, Er-He; Yang, Jian; Yang, Li-Fang

Xu, Chen-Nian; Kong, Ling-Heng; Ding, Peng; Liu, Yang; Fan, Zhen-Ge; Gao, Er-He; Yang, Jian; Yang, Li-Fang.

Afiliação

Xu CN; Department of Cardiovascular Surgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.
Kong LH; Department of Cardiovascular Surgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China; School of Basic Medical Science, Xi'an Medical University, Xi'an 710021, China.
Ding P; Department of Cardiovascular Surgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.
Liu Y; Department of Cardiovascular Surgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.
Fan ZG; Department of Cardiovascular Surgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.
Gao EH; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Yang J; Department of Cardiovascular Surgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China. Electronic address: yangjian1212@hotmail.com.
Yang LF; Department of Anesthesiology, Xi'an Children's Hospital, Xi'an 710003, China. Electronic address: yanglf@fmmu.edu.cn.

Biochim Biophys Acta Mol Basis Dis ; 1866(10): 165848, 2020 10 01.

Article em En | MEDLINE | ID: mdl-32473999

Assuntos

Proteína 5 Relacionada à Autofagia/metabolismo; Autofagia/efeitos dos fármacos; Cardiomegalia/tratamento farmacológico; Melatonina/farmacologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Serina-Treonina Quinases TOR/metabolismo; Animais; Apoptose; Cardiomegalia/metabolismo; Cardiomegalia/patologia; Modelos Animais de Doenças; Fibrose; Insuficiência Cardíaca/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

Akt/mTOR pathway; Atg5; Autophagy; Hypertrophy; Melatonin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Cardiomegalia / Proteínas Proto-Oncogênicas c-akt / Serina-Treonina Quinases TOR / Proteína 5 Relacionada à Autofagia / Melatonina Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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