Effects of anti-osteoporosis therapy on plasma aldosterone and renin.
J Renin Angiotensin Aldosterone Syst
; 21(2): 1470320320928874, 2020.
Article
em En
| MEDLINE
| ID: mdl-32482112
ABSTRACT
OBJECTIVE:
This study aimed to investigate the effect of anti-osteoporosis therapy on plasma aldosterone concentration (PAC), plasma renin concentration (PRC) and the aldosterone/renin ratio (ARR) in patients with postmenopausal osteoporosis.METHODS:
In 60 patients with postmenopausal osteoporosis, bone mineral density (BMD), PAC and PRC were measured before and after treatment with alendronate (70 mg/week, n=22) or recombinant human parathyroid hormone (20 µg/day, n=35) for 48 weeks.RESULTS:
PAC was negatively correlated with the T-score of lumbar spine BMD and femoral neck BMD (lumbar r=-0.386, p<0.01; femoral neck r=-0.262, p<0.05). With the improvement in lumbar BMD after anti-osteoporosis treatment (T-score -3.4±0.5 vs. -3.1 ±0.4, p<0.0001), PAC decreased from 182.8±53.2 to 143.7±68.6 pg/mL (p<0.0001), PRC increased from 7.8±11.6 to 39.2±50.0 µIU/mL (p<0.0001) and the ARR decreased from 74.8±75.2 to 13.1±17.1 pg/µIU (p<0.0001). At baseline, 58% (35/60) of the patients had an ARR >37 pg/µIU, and the proportion decreased to 8% (5/57) after treatment.CONCLUSION:
Treatment with alendronate or parathyroid hormone causes decreased PAC and increased PRC, resulting in a decreased ARR in postmenopausal women with osteoporosis.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoporose Pós-Menopausa
/
Renina
/
Aldosterona
/
Conservadores da Densidade Óssea
Tipo de estudo:
Clinical_trials
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article