Dopaminergic symptoms in migraine: A cross-sectional study on 1148 consecutive headache center-based patients.
Cephalalgia
; 40(11): 1168-1176, 2020 10.
Article
em En
| MEDLINE
| ID: mdl-32484361
ABSTRACT
BACKGROUND:
Dopaminergic symptoms may be extremely pronounced in some migraine patients during the attack, representing a major source of disability.OBJECTIVES:
We aimed to carefully characterize the clinical picture of migraine patients with dopaminergic symptoms in a large patients' population as a putative migraine endophenotype, allowing more precise disease management, treatment and outcome prediction.METHODS:
We screened 1148 consecutive tertiary care episodic and chronic migraine patients with face-to-face interviews collecting thorough data on lifestyle, socio-demographic factors, and clinical migraine features.RESULTS:
We identified 374 patients with migraine with dopaminergic symptoms (32.6%). The most frequent dopaminergic symptom was yawning followed by somnolence, nausea, vomiting, fatigue, mood changes and diuresis. Migraine patients with dopaminergic symptoms had longer attack duration (OR 1.82; 95% CI 1.41-2.36, p < 0.0001), more frequent osmophobia (OR 2.01; 95% CI 1.50-2.69, p < 0.0001), allodynia (OR 1.43; 95% CI 1.10-1.85, p = 0.0071) and unilateral cranial autonomic symptoms (OR 1.31; 95% CI 1.01-1.68, p = 0.045), but used less preventative treatments (OR 0.74; 95% CI 0.57-0.98, p = 0.033) than patients without dopaminergic symptoms.CONCLUSIONS:
Migraine patients with dopaminergic symptoms are characterized by a full-blown, more disabling migraine. Dopaminergic system modulation should be carefully considered in individuals with migraine with dopaminergic symptoms for both acute and preventative treatments in future ad hoc designed studies.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos de Enxaqueca
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Qualitative_research
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article