FTY720 reactivates cryptococcal granulomas in mice through S1P receptor 3 on macrophages.

Bryan, Arielle M; You, Jeehyun Karen; McQuiston, Travis; Lazzarini, Cristina; Qiu, Zhijuan; Sheridan, Brian; Nuesslein-Hildesheim, Barbara; Del Poeta, Maurizio

Bryan, Arielle M; You, Jeehyun Karen; McQuiston, Travis; Lazzarini, Cristina; Qiu, Zhijuan; Sheridan, Brian; Nuesslein-Hildesheim, Barbara; Del Poeta, Maurizio.

Afiliação

Bryan AM; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.
You JK; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.
McQuiston T; FirstString Research Inc., Mount Pleasant, South Carolina, USA.
Lazzarini C; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.
Qiu Z; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.
Sheridan B; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.
Nuesslein-Hildesheim B; Novartis Institute for Biomedical Research, Novartis Pharma AG, Basel, Switzerland.
Del Poeta M; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.

J Clin Invest ; 130(9): 4546-4560, 2020 09 01.

Article em En | MEDLINE | ID: mdl-32484801

Assuntos

Criptococose/tratamento farmacológico; Cryptococcus neoformans/metabolismo; Cloridrato de Fingolimode/farmacologia; Granuloma/tratamento farmacológico; Macrófagos Peritoneais/metabolismo; Receptores de Esfingosina-1-Fosfato/metabolismo; Animais; Linhagem Celular; Criptococose/metabolismo; Criptococose/patologia; Feminino; Granuloma/metabolismo; Granuloma/microbiologia; Granuloma/patologia; Humanos; Macrófagos Peritoneais/microbiologia; Macrófagos Peritoneais/patologia; Masculino; Camundongos

Palavras-chave

Fungal infections; Immunology; Infectious disease; Macrophages; Multiple sclerosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Macrófagos Peritoneais / Criptococose / Cryptococcus neoformans / Cloridrato de Fingolimode / Receptores de Esfingosina-1-Fosfato / Granuloma Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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