Genetic architecture of Environmental Sensitivity reflects multiple heritable components: a twin study with adolescents.
Mol Psychiatry
; 26(9): 4896-4904, 2021 09.
Article
em En
| MEDLINE
| ID: mdl-32488124
ABSTRACT
Humans differ substantially in how strongly they respond to similar experiences. Theory suggests that such individual differences in susceptibility to environmental influences have a genetic basis. The present study investigated the genetic architecture of Environmental Sensitivity (ES) by estimating its heritability, exploring the presence of multiple heritable components and its genetic overlap with common personality traits. ES was measured with the Highly Sensitive Child (HSC) questionnaire and heritability estimates were obtained using classic twin design methodology in a sample of 2868 adolescent twins. Results indicate that the heritability of sensitivity was 0.47, and that the genetic influences underlying sensitivity to negative experiences are relatively distinct from sensitivity to more positive aspects of the environment, supporting a multi-dimensional genetic model of ES. The correlation between sensitivity, neuroticism and extraversion was largely explained by shared genetic influences, with differences between these traits mainly attributed to unique environmental influences operating on each trait.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gêmeos
/
Modelos Genéticos
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
/
Child
/
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article