Transcranial Sonography Findings in Alzheimer's Disease: A New Imaging Biomarker.
Ultraschall Med
; 42(6): 623-633, 2021 Dec.
Article
em En
| MEDLINE
| ID: mdl-32492728
ABSTRACT
OBJECTIVE:
To validate transcranial sonography (TCS) as a novel imaging tool for the assessment of medial temporal lobe (MTL) atrophy (MTA). MATERIALS ANDMETHODS:
Participants with Alzheimer's disease (AD, nâ=â30) and age-sex-matched controls (nâ=â30) underwent TCS and MRI. On TCS, MTL structures (choroidal fissure (CF) and temporal horn (TH)) were measured and combined to create an MTA score in sonography (MTA-S). Furthermore, both THs and the third ventricle were combined to form the ventricle enlargement score in sonography (VES-S). On MRI, the MTL was evaluated by linear measurements, MTA scale and hippocampal volumetry. Validation was performed by comparing imaging methods and the patient group.RESULTS:
Intraclass correlations for CF and TH showed substantial intra/inter-rater reliability (>â0.80). TCS and MRI showed strong to moderate correlation regarding TH (rightâ=â0.88, leftâ=â0.89) and CF (rightâ=â0.70, leftâ=â0.47). MTA-S correlated significantly with the hippocampal volume (rightâ=â-0.51, leftâ=â-0.47), predicted group membership in logistic regression (Exp(B) rightâ=â3.0, leftâ=â2.7), and could separate AD patients from controls (AUCâ=â0.93). An MTA-S of 6âmm and 10âmm discriminated MRI MTA scores 0-1 (from 2-4) and MTA score 4 (from 0-3) with 100â% specificity, respectively. VES-S also showed a moderate correlation with the hippocampal volume (râ=â-0.66) and could differentiate ADâpatients from controls (AUCâ=â0.93).CONCLUSION:
Our results suggest that TCS may be an alternative imaging tool for the assessment of MTL atrophy and ventricular enlargement for patients in whom MRI scanning is not possible. Additionally, TCS offers a practical, patient-friendly and inexpensive option for the screening and follow-up of individuals with AD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Alzheimer
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article