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Saikosaponin A inhibits the activation of pancreatic stellate cells by suppressing autophagy and the NLRP3 inflammasome via the AMPK/mTOR pathway.
Cui, Lihua; Li, Caixia; Zhuo, Yuzhen; Yang, Lei; Cui, Naiqiang; Li, Yuhong; Zhang, Shukun.
Afiliação
  • Cui L; Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Tianjin 300100, China; Nankai Clinical College, Tianjin Medical University, Tianjin 300107,
  • Li C; Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Tianjin 300100, China; Nankai Clinical College, Tianjin Medical University, Tianjin 300107,
  • Zhuo Y; Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Tianjin 300100, China; Nankai Clinical College, Tianjin Medical University, Tianjin 300107,
  • Yang L; Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Tianjin 300100, China; Nankai Clinical College, Tianjin Medical University, Tianjin 300107,
  • Cui N; Department of Hepatobiliary and Pancreatic Surgery, Tianjin Nankai Hospital, Tianjin 300100, China; Nankai Clinical College, Tianjin Medical University, Tianjin 300107, China.
  • Li Y; Institute of TCM, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. Electronic address: liyuhong@tjutcm.edu.cn.
  • Zhang S; Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Tianjin 300100, China; Nankai Clinical College, Tianjin Medical University, Tianjin 300107,
Biomed Pharmacother ; 128: 110216, 2020 Aug.
Article em En | MEDLINE | ID: mdl-32497863
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Oleanólico / Saponinas / Autofagia / Proteínas Quinases Ativadas por AMP / Células Estreladas do Pâncreas / Inflamassomos / Serina-Treonina Quinases TOR / Proteína 3 que Contém Domínio de Pirina da Família NLR Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Oleanólico / Saponinas / Autofagia / Proteínas Quinases Ativadas por AMP / Células Estreladas do Pâncreas / Inflamassomos / Serina-Treonina Quinases TOR / Proteína 3 que Contém Domínio de Pirina da Família NLR Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article