Your browser doesn't support javascript.
loading
Acetylcholinesterase inhibition prevents alterations in cardiovascular autonomic control and gastric motility in L-NAME-induced hypertensive rats.
Cavalcante, Gisele Lopes; Ferreira, Francislando Nascimento; da Silva, Moisés Tolentino Bento; Soriano, Renato Nery; Filho, Antônio Luiz Martins Maia; Arcanjo, Daniel Dias Rufino; Sabino, João Paulo Jacob.
Afiliação
  • Cavalcante GL; Department of Biophysics and Physiology, Postgraduate Program in Pharmaceutical Sciences and Laboratory of Blood Pressure and Ventilation Control, Federal University of Piaui, Teresina, PI, Brazil.
  • Ferreira FN; Department of Biophysics and Physiology, Postgraduate Program in Pharmaceutical Sciences and Laboratory of Blood Pressure and Ventilation Control, Federal University of Piaui, Teresina, PI, Brazil.
  • da Silva MTB; Department of Physical Education, Laboratory of Exercise and Gastrointestinal Tract, Federal University of Piaui, Teresina, PI, Brazil.
  • Soriano RN; Division of Physiology and Biophysics, Department of Basic Life Sciences, Federal University of Juiz de Fora, Governador Valadares, MG, Brazil.
  • Filho ALMM; Nucleus of Research in Biotechnology - State University of Piaui, Teresina, PI, Brazil.
  • Arcanjo DDR; Department of Biophysics and Physiology, Postgraduate Program in Pharmaceutical Sciences and Laboratory of Blood Pressure and Ventilation Control, Federal University of Piaui, Teresina, PI, Brazil.
  • Sabino JPJ; Department of Biophysics and Physiology, Postgraduate Program in Pharmaceutical Sciences and Laboratory of Blood Pressure and Ventilation Control, Federal University of Piaui, Teresina, PI, Brazil. Electronic address: jacobsabino@ufpi.edu.br.
Life Sci ; 256: 117915, 2020 Sep 01.
Article em En | MEDLINE | ID: mdl-32504752
AIMS: Autonomic dysfunction in arterial hypertension affects cardiorespiratory control and gastric motility and has been characterized by increased sympathetic and reduced parasympathetic activity. In the present work we investigated the effects of anticholinesterase drugs [donepezil (DON) or pyridostigmine (PYR)] on cardiovascular, autonomic, and gastric parameters in L-NAME-induced hypertensive rats. MATERIALS AND METHODS: Daily oral gavage of L-NAME (70 mg/kg/day) was performed over 14 days in male Wistar rats (180-220 g), whereas daily oral gavage of DON or PYR (1.6 and 22 mg/kg/day, respectively) started 2 days after the L-NAME treatment initiation and lasted 12 days. The development of hypertension was verified by tail plethysmography technique. After the end of treatments, the animals were subjected to experimental protocols (6-12 animals per group; total number of animals used: 78). KEY FINDINGS: L-NAME hypertensive animals had no alterations in heart rate (HR) and intrinsic HR, but showed reduction in baroreflex sensitivity, parasympathetic tone, and gastric motility; and the sympathetic tone, chemoreflex sensitivity, and the LF (low frequency) band of systolic arterial pressure (SAP) variability were increased. DON or PYR attenuated the increase in mean arterial pressure (MAP) induced by L-NAME. Both anticholinesterase drugs were effective in preventing the decrease in baroreflex sensitivity, parasympathetic tone and gastric motility, and also prevented the increases in peripheral chemoreflex response and cardiac sympathetic tone. SIGNIFICANCE: Acetylcholinesterase inhibition with DON or PYR is a promising pharmacological approach to increase parasympathetic function, thus preventing the hypertension-induced alterations in the cardiovascular, gastrointestinal and autonomic systems.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Brometo de Piridostigmina / Inibidores da Colinesterase / NG-Nitroarginina Metil Éster / Substâncias Protetoras / Hipertensão Tipo de estudo: Guideline / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Brometo de Piridostigmina / Inibidores da Colinesterase / NG-Nitroarginina Metil Éster / Substâncias Protetoras / Hipertensão Tipo de estudo: Guideline / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article