Structure-based discovery of the endocrine disrupting effects of hydraulic fracturing chemicals as novel androgen receptor antagonists.

Tachachartvanich, Phum; Azhagiya Singam, Ettayapuram Ramaprasad; Durkin, Kathleen A; Smith, Martyn T; La Merrill, Michele A

Tachachartvanich, Phum; Azhagiya Singam, Ettayapuram Ramaprasad; Durkin, Kathleen A; Smith, Martyn T; La Merrill, Michele A.

Afiliação

Tachachartvanich P; Department of Environmental Toxicology, University of California, Davis, CA, 95616, USA.
Azhagiya Singam ER; Molecular Graphics and Computation Facility, College of Chemistry, University of California, Berkeley, CA, 94720, USA.
Durkin KA; Molecular Graphics and Computation Facility, College of Chemistry, University of California, Berkeley, CA, 94720, USA.
Smith MT; Division of Environmental Health Sciences, School of Public Health, University of California Berkeley, CA, 94720, USA.
La Merrill MA; Department of Environmental Toxicology, University of California, Davis, CA, 95616, USA. Electronic address: mlamerrill@ucdavis.edu.

Chemosphere ; 257: 127178, 2020 Oct.

Article em En | MEDLINE | ID: mdl-32505947

Assuntos

Disruptores Endócrinos/toxicidade; Antagonistas de Androgênios/química; Antagonistas de Receptores de Andrógenos/farmacologia; Androgênios; Disruptores Endócrinos/química; Humanos; Fraturamento Hidráulico; Simulação de Acoplamento Molecular; Receptores Androgênicos/metabolismo

Palavras-chave

Androgen receptor; Antiandrogens; Endocrine disruptors; Fracking; Molecular docking

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disruptores Endócrinos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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