Desensitizing highly sensitized heart transplant candidates with the combination of belatacept and proteasome inhibition.

Alishetti, Shudhanshu; Farr, Maryjane; Jennings, Douglas; Serban, Geo; Uriel, Nir; Sayer, Gabriel; Vasilescu, Rodica; Restaino, Susan; Chong, Anita S; Habal, Marlena V

Alishetti, Shudhanshu; Farr, Maryjane; Jennings, Douglas; Serban, Geo; Uriel, Nir; Sayer, Gabriel; Vasilescu, Rodica; Restaino, Susan; Chong, Anita S; Habal, Marlena V.

Afiliação

Alishetti S; Department of Medicine, Division of Cardiology, Columbia University Irving Medical Center, New York, New York, USA.
Farr M; Department of Medicine, Division of Cardiology, Columbia University Irving Medical Center, New York, New York, USA.
Jennings D; Department of Pharmacy Practice, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, New York, New York, USA.
Serban G; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, USA.
Uriel N; Department of Medicine, Division of Cardiology, Columbia University Irving Medical Center, New York, New York, USA.
Sayer G; Department of Medicine, Division of Cardiology, Columbia University Irving Medical Center, New York, New York, USA.
Vasilescu R; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, USA.
Restaino S; Department of Medicine, Division of Cardiology, Columbia University Irving Medical Center, New York, New York, USA.
Chong AS; Department of Surgery, University of Chicago, Chicago, Illinois, USA.
Habal MV; Department of Medicine, Division of Cardiology, Columbia University Irving Medical Center, New York, New York, USA.

Am J Transplant ; 20(12): 3620-3630, 2020 12.

Article em En | MEDLINE | ID: mdl-32506824

Assuntos

Transplante de Coração; Complexo de Endopeptidases do Proteassoma; Abatacepte/uso terapêutico; Rejeição de Enxerto/tratamento farmacológico; Rejeição de Enxerto/prevenção & controle; Antígenos HLA; Teste de Histocompatibilidade; Isoanticorpos; Leucócitos Mononucleares

Palavras-chave

costimulation; desensitization; heart transplantation/cardiology; histocompatibility; immunosuppressant-fusion proteins and monoclonal antibodies: belatacept; immunosuppression/immune modulation; natural killer (NK) cells/NK receptors; sensitization; translational research/science

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Coração / Complexo de Endopeptidases do Proteassoma Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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