Denervation findings on EMG in amyotrophic lateral sclerosis and correlation with prognostic milestones: Data from a retrospective study.
Clin Neurophysiol
; 131(8): 2017-2022, 2020 08.
Article
em En
| MEDLINE
| ID: mdl-32507653
ABSTRACT
OBJECTIVE:
To verify whether the finding of denervation activity on EMG at the time of diagnosis has a prognostic value in amyotrophic lateral sclerosis (ALS).METHODS:
We retrospectively studied all the patients discharged with a diagnosis of ALS between January 2009 and January 2017. 92 patients met the inclusion criteria. We mainly verified three prognostic targetsAll EMG examinations were reviewed and a denervation score (DS) was calculated. The association of DS with clinical milestones was analysed, adjusting for disease duration, age , sex, and clinical phenotype.RESULTS:
We found a significant association between bulbar DS and time to NIV/tracheostomy (HR 3.34, 95% CI 1.49 to 7.48, p = 0.002) and with survival (HR 3.633, 95% CI 1.681-7.848, p = 0.001), regardless of the clinical phenotype. Furthermore, we found a significant influence of a general DS on survival (HR 2.62, 95% CI 1.335-5.160, p = 0.005).CONCLUSION:
EMG assessment could be of value not just for ALS diagnosis but also for its intrinsic prognostic value.SIGNIFICANCE:
EMG could provide additional information about the rate of progression of ALS as early as the diagnosis is made.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Eletromiografia
/
Esclerose Lateral Amiotrófica
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article