The DNA damage response pathway as a land of therapeutic opportunities for colorectal cancer.

Mauri, G; Arena, S; Siena, S; Bardelli, A; Sartore-Bianchi, A

Mauri, G; Arena, S; Siena, S; Bardelli, A; Sartore-Bianchi, A.

Afiliação

Mauri G; Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy.
Arena S; Candiolo Cancer Institute, FPO - IRCCS, Candiolo (TO), Torino, Italy; Department of Oncology, University of Torino, Candiolo (TO), Italy. Electronic address: sabrina.arena@unito.it.
Siena S; Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy.
Bardelli A; Candiolo Cancer Institute, FPO - IRCCS, Candiolo (TO), Torino, Italy; Department of Oncology, University of Torino, Candiolo (TO), Italy. Electronic address: alberto.bardelli@unito.it.
Sartore-Bianchi A; Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy. Electronic address: andrea.sartorebianchi@unimi.it.

Ann Oncol ; 31(9): 1135-1147, 2020 09.

Article em En | MEDLINE | ID: mdl-32512040

Assuntos

Neoplasias do Colo; Neoplasias Colorretais; Neoplasias Colorretais/tratamento farmacológico; Neoplasias Colorretais/genética; Dano ao DNA; Humanos; Platina/uso terapêutico; Inibidores de Poli(ADP-Ribose) Polimerases/uso terapêutico

Palavras-chave

ATM; BRCA; DNA damage response; PARP inhibitors; PARPness; colorectal cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Neoplasias do Colo Tipo de estudo: Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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