An effective method to produce 7-epitaxol from taxol in HCO3.
Bioorg Med Chem Lett
; 30(15): 127285, 2020 08 01.
Article
em En
| MEDLINE
| ID: mdl-32527458
ABSTRACT
It is known that 7-epitaxol has much stronger cytotoxicity than taxol does. However, the content of 7-epitaxol in yew is much less than taxol, which makes it more costly to obtain. We describe here a method to effectively convert taxol to 7-epitaxol. The key condition for reaction needs NaHCO3 in solvent acetonitrile (ACN). The conversion rate can be over 82%.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paclitaxel
/
Bicarbonato de Sódio
/
Antifúngicos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article