An effective method to produce 7-epitaxol from taxol in HCO<sub>3</sub><sup>.</sup>

Liu, Yanjie; Ma, Xiaoyu; Zhou, Mengkai; Hao, Xiaoran; Zhu, Xudong

An effective method to produce 7-epitaxol from taxol in HCO₃^.

Liu, Yanjie; Ma, Xiaoyu; Zhou, Mengkai; Hao, Xiaoran; Zhu, Xudong.

Afiliação

Liu Y; Beijing Key Laboratory of Genetic Engineering Drug and Biotechnology, Institute of Biochemistry and Biotechnology, College of Life Science, Beijing Normal University, Beijing 100875, PR China.
Ma X; Beijing Key Laboratory of Genetic Engineering Drug and Biotechnology, Institute of Biochemistry and Biotechnology, College of Life Science, Beijing Normal University, Beijing 100875, PR China.
Zhou M; Beijing Key Laboratory of Genetic Engineering Drug and Biotechnology, Institute of Biochemistry and Biotechnology, College of Life Science, Beijing Normal University, Beijing 100875, PR China.
Hao X; Beijing Key Laboratory of Genetic Engineering Drug and Biotechnology, Institute of Biochemistry and Biotechnology, College of Life Science, Beijing Normal University, Beijing 100875, PR China.
Zhu X; Beijing Key Laboratory of Genetic Engineering Drug and Biotechnology, Institute of Biochemistry and Biotechnology, College of Life Science, Beijing Normal University, Beijing 100875, PR China. Electronic address: zhu11187@bnu.edu.cn.

Bioorg Med Chem Lett ; 30(15): 127285, 2020 08 01.

Article em En | MEDLINE | ID: mdl-32527458

ABSTRACT

ABSTRACT

It is known that 7-epitaxol has much stronger cytotoxicity than taxol does. However, the content of 7-epitaxol in yew is much less than taxol, which makes it more costly to obtain. We describe here a method to effectively convert taxol to 7-epitaxol. The key condition for reaction needs NaHCO3 in solvent acetonitrile (ACN). The conversion rate can be over 82%.

Assuntos

Antifúngicos/síntese química; Paclitaxel/síntese química; Bicarbonato de Sódio/química; Acetonitrilas/química; Antifúngicos/química; Antifúngicos/farmacologia; Testes de Sensibilidade Microbiana; Conformação Molecular; Paclitaxel/análogos & derivados; Paclitaxel/química; Paclitaxel/farmacologia; Saccharomyces cerevisiae/efeitos dos fármacos

Palavras-chave

7-Epitaxol; Acetonitrile; Epimerization; HCO(3)(); Taxol

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paclitaxel / Bicarbonato de Sódio / Antifúngicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google