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Design and synthesis of C-12 dithiocarbamate andrographolide analogues as an anticancer agent.
Arsakhant, Patcharee; Sirion, Uthaiwan; Chairoungdua, Arthit; Suksen, Kanoknetr; Piyachaturawat, Pawinee; Suksamrarn, Apichart; Saeeng, Rungnapha.
Afiliação
  • Arsakhant P; Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Burapha University, Chonburi 20131, Thailand.
  • Sirion U; Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Burapha University, Chonburi 20131, Thailand; The Research Unit in Synthetic Compounds and Synthetic Analogues from Natural Product for Drug Discovery (RSND), Burapha University, Chonburi 20131, Thailand.
  • Chairoungdua A; Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
  • Suksen K; Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
  • Piyachaturawat P; Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
  • Suksamrarn A; Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand.
  • Saeeng R; Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Burapha University, Chonburi 20131, Thailand; The Research Unit in Synthetic Compounds and Synthetic Analogues from Natural Product for Drug Discovery (RSND), Burapha University, Chonburi 20131, Thailand. Electronic
Bioorg Med Chem Lett ; 30(14): 127263, 2020 07 15.
Article em En | MEDLINE | ID: mdl-32527561
A series of 21 new analogues of C-12 dithiocarbamate andrographolide was designed and synthesized from natural andrographolide isolated from a common Thai plant, Andrographis paniculata. The reaction used to manipulate the andrographolide scaffold was conducted in one pot under mild reaction conditions. This avoided toxic catalysts and gave nearly quantitative yields of new analogues, generally without by-products and can be easily scaled -up for industrial processing. All new analogues were evaluated against nine cancer cell lines, some analogues exhibited greater selective cytotoxic activity to MCF-7 cancer cell than that of the parent andrographolide and cancer drugs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Andrographis / Diterpenos / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Andrographis / Diterpenos / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article